Rab27a
نویسندگان
چکیده
منابع مشابه
Rab27a
Normal pigmentation depends on the uniform distribution of melanin-containing vesicles, the melanosomes, in the epidermis. Griscelli syndrome (GS) is a rare autosomal recessive disease, characterized by an immune deficiency and a partial albinism that has been ascribed to an abnormal melanosome distribution. GS maps to 15q21 and was first associated with mutations in the myosin-V gene. However,...
متن کاملRAB27A Mutation in Griscelli Syndrome
1Department of Pediatric Hematology/Oncology, Mofi d Children Hospital, Shahid Beheshti Medical University, Tehran, Iran 2Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 3Research Center for Immunodefi ciencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Scie...
متن کاملDistinct Rab27A binding affinities of Slp2-a and Slac2-a/melanophilin: Hierarchy of Rab27A effectors.
The small GTPase Rab27A has recently been shown to regulate melanosome transport in mammalian skin melanocytes through sequentially interacting with two Rab27A effectors, Slac2-a/melanophilin and Slp2-a. Although Slac2-a and Slp2-a contain a similar N-terminal Rab27A-binding domain (named SHD, Slp homology domain), nothing is known about the functional differences between the Slac2-a SHD and Sl...
متن کاملRab27a Is Required for Human Cytomegalovirus Assembly
Human cytomegalovirus (HCMV) completes its final envelopment on intracellular membranes before it is released from the cell. The mechanisms underlying these processes are not understood. Here we studied the role of Rab27a, a regulator of lysosome-related organelle transport, in HCMV production. HCMV infection increased Rab27a expression, and recruitment of Rab27a to membranous strutures at the ...
متن کاملRab27a builds a platform for HIV-1
O'Regan et al. reveal that the mitotic kinase Nek6 targets the chaperone Hsp72 to the mitotic spindle, where it promotes the formation of stable K-fi bers. Nek6 is required for robust spindle assembly and mitotic progression, but its substrates are largely unknown. O'Regan et al. found that the kinase bound to Hsp72 and, during mitosis, phosphory-lated a conserved threonine residue in the chape...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.152.4.843